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The discovery of TAK-875.

Journal: Drug Design, Development and Therapy

Article Title: Recent Developments in Drug Design of Oral Synthetic Free Fatty Acid Receptor 1 Agonists

doi: 10.2147/DDDT.S487469

Figure Lengend Snippet: The discovery of TAK-875.

Article Snippet: shows how Takeda scientists discovered fasiglifam (TAK-875).

Techniques:

Structure of FFAR1 with TAK-875. ( a ) the common seven-helix bundle is shown as rainbow-colored ribbons, while TAK-875, positioned between helix 3 and helix 4, is displayed as a stick model; ( b ) the top view of FFAR1 and mesh pattern demonstrates binding pocket; ( c ) the computational model shows how TAK-875 interacts with FFAR1 in binding pocket.

Journal: Drug Design, Development and Therapy

Article Title: Recent Developments in Drug Design of Oral Synthetic Free Fatty Acid Receptor 1 Agonists

doi: 10.2147/DDDT.S487469

Figure Lengend Snippet: Structure of FFAR1 with TAK-875. ( a ) the common seven-helix bundle is shown as rainbow-colored ribbons, while TAK-875, positioned between helix 3 and helix 4, is displayed as a stick model; ( b ) the top view of FFAR1 and mesh pattern demonstrates binding pocket; ( c ) the computational model shows how TAK-875 interacts with FFAR1 in binding pocket.

Article Snippet: shows how Takeda scientists discovered fasiglifam (TAK-875).

Techniques: Binding Assay

The design of CPL207280 and its clinical applied state with TAK-875 as reference.

Journal: Drug Design, Development and Therapy

Article Title: Recent Developments in Drug Design of Oral Synthetic Free Fatty Acid Receptor 1 Agonists

doi: 10.2147/DDDT.S487469

Figure Lengend Snippet: The design of CPL207280 and its clinical applied state with TAK-875 as reference.

Article Snippet: shows how Takeda scientists discovered fasiglifam (TAK-875).

Techniques:

( a ) Interactions between FFAR1 and selected compounds; ( b ) structures of three lead compounds and TAK-875.

Journal: Drug Design, Development and Therapy

Article Title: Recent Developments in Drug Design of Oral Synthetic Free Fatty Acid Receptor 1 Agonists

doi: 10.2147/DDDT.S487469

Figure Lengend Snippet: ( a ) Interactions between FFAR1 and selected compounds; ( b ) structures of three lead compounds and TAK-875.

Article Snippet: shows how Takeda scientists discovered fasiglifam (TAK-875).

Techniques: